The working environment of the wiring harness of the car is very harsh, often accompanied by corrosive gases and liquids, as well as high temperature, humidity, and collision and friction with other parts, often causing damage to the insulator coat, loose interfaces, etc., resulting in short circuits in the wiring harness Or break the circuit, which will affect the overall electronic system. Therefore, in order to improve the safety of automotive wiring harness design, it is necessary to make a work plan for wiring harness design, and effectively wrap and fix the wiring harness. The design of automobile wiring harness should have measures such as moisture-proof, anti-corrosion and anti-high temperature, and at the same time, it must be ensured that it has good airtight materials to protect the joints and connectors. When installing the wiring harness on other parts of the car body, use professional cable ties and wire clips to fix it to reduce the impact of vibration on the car wiring harness during driving. At the same time, for some connection positions, it is necessary to protect them to avoid the friction between the remote control and the wiring harness, which will cause the wear of the insulating coat. When packaging, it is necessary to analyze the different operating environments of different components to characterize their service life and reliability. It is necessary to conduct various comparative tests on the materials, and then select the appropriate materials. It is also necessary to conduct experiments on the reliability of the wiring harness in harsh environments to prevent unqualified products from flowing into the next link.